Endocrine Abstracts

Aim: Traumatic brain injury (TBI) is known to be associated with pituitary insufficiency (PI). We have recently shown that there was a relationship between miR-126-3p, miR-3610 and PI developing in follow up of patients with TBI. In this study, we aimed to test the effects of miR-126-3p on hypothalamus pituitary-adrenal (HPA) and Growth hormone-Insulin like growth factor (GH-IGF-1) axes.Materials and methods: miR126-3p microinjection was performed to mou...

Several instances of RNA-mediated inheritance of phenotypic variation have been reported, among them metabolic disorders. We and others have observed that microinjection into naive fertilized mouse eggs of total sperm RNAs of obese and diabetic males maintained on high-fat diet induce the same pathological variation in the offspring. A role of noncoding RNAs is currently the prevailing hypothesis.The sperm RNA content is complex. It depends on environmen...